Scientist, Assay Research at Mammoth Biosciences
South San Francisco, CA, US
Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and Casɸ, Mammoth Biosciences can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Mammoth is democratizing disease detection with easy and affordable point-of-care tests that allow real-time and simultaneous detection of multiple conditions, along with high-throughput tests that allow for unprecedented testing volume. Further, the company is transforming disease treatment with its proprietary micro-sized CRISPR proteins that enable new editing and delivery options. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber. 
Mammoth is seeking a Scientist with expertise in nucleic acid chemistry, nucleic acid amplification technologies, and/or CRISPR technologies to join its Diagnostic team.
The successful candidate will be responsible for developing creative solutions to enhance our CRISPR-based diagnostic assays. The scope of the work will include (i) nucleic acid conjugation to proteins and surfaces, (ii) optimizing and evaluating nucleic acid amplification methods, and (iii) developing and evaluating novel CRISPR reagents. 


    • Design and execute experiments to enhance the capabilities of Mammoth’s CRISPR-Cas proteins for diagnostic applications
    • Conduct hands-on-experiments for nucleic acid extraction, amplification, and related assays
    • Work with team lead to set quarterly and annual goals that contribute to the Applied group’s objectives
    • Develop assays, tools, and infrastructure for testing and evaluating new readout chemistries
    • Document and regularly present experimental results at internal meetings
    • Train and mentor Research Associates
    • Coordinate with Research Associates and Engineering teams to execute experiments


    • PhD in biochemistry, molecular biology, bioengineering or a related discipline, plus 1 year of experience in the biotechnology industry


    • Experience with CRISPR-Cas systems such as Cas9, Cas12, Cas13, or Cas14
    • Expertise in molecular biology, biochemistry, and related fields
    • Experience immobilizing proteins or nucleic acids to surfaces
    • Familiarity with isothermal amplification methods
    • Comfortable with data analysis (JMP, R, python) and DoE


    • Competitive salary with equity
    • Full health/vision/dental benefits
    • Unlimited vacation
    • Free breakfast/lunch/dinner/barista
    • Free gym
    • Public transportation commuter subsidy
    • 401(k) matching