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Sr. Scientist Downstream Viral Vector

Adicet Bio

Menlo Park, CA, US
  • Job Type: Full-Time
  • Function: Life Sciences R&D/Engineering
  • Industry: BioPharma
  • Post Date: 04/15/2021
  • Website: adicetbio.com
  • Company Address: 200 Constitution Drive, Menlo Park, CA, 94025

About Adicet Bio

Adicet Bio, Inc. is a privately held, pre-clinical stage biotechnology company engaged in the design and development of cutting-edge immunotherapies with initial focus on cancer. Adicet is developing novel universal immune cell therapies based on gamma delta T cells engineered with Chimeric Antigen Receptors (CARs) or T Cell Receptors (TCRs).

Job Description

Adicet Bio, Inc. is a  biotechnology company founded in 2015 focused on the development of novel off-the-shelf allogeneic gamma delta T cell immune cell therapies for oncology and other indications.   resTORbio, Inc. is a public, clinical-stage biopharmaceutical company that has been focused on developing innovative medicines that target the biology of aging to treat aging-related diseases. On April 29, 2020, resTORbio and Adicet announced a reverse merger which is expected to close in the second half of  2020. The resulting publicly-traded company, “Adicet Bio”, will focus on progressing Adicet’s proprietary gamma delta T cell therapy platform.  Adicet expects to initiate clinical development of ADI-001 by the end of 2020 or early 2021. Adicet’s second product candidate, ADI-002 subject to the FDA regulatory process for review of INDs, Adicet intends to file  an IND and, subject to the FDA regulatory process for review of IND’s, initiate a Phase 1 clinical trial in 2021.

Adicet’s solid tumor efforts are further complemented by the company’s proprietary T cell receptor-like antibody, or TCRL, platform technology, which enables the generation of CARs that recognize tumor antigens inside tumor cells, otherwise known as intracellular proteins.  Adicet believes the ability to selectively bind to tumor antigens derived specifically from intracellular proteins is a critical advantage to immunocellular therapy due to the scarcity of tumor-specific surface antigens on solid tumors.  Adicet’s approach to generating CARs for some product candidates takes advantage of this ability.

SENIOR SCIENTIST, DOWNSTREAM VIRAL VECTOR GROUP

Adicet Bio is developing a next generation manufacturing process to advance our platform of “off-the-shelf” immune cell products. We are currently seeking individuals for our viral vector group as we advance our production platforms. The position offers a chance to be part of a highly motivated team, applying the latest cell culture and bioprocessing practices to facilitate development of our proprietary cell therapies.

We are currently seeking an energetic and experienced individual with a strong materials purification background to join our downstream viral vector team. The successful candidate will contribute to the advancement of Adicet’s production platform by developing, characterizing, and optimizing vector purification procedures designed to support both research and manufacturing pipelines.

The individual will serve as the technical lead for a team of junior scientists and will work in collaboration with Upstream and Analytical vector teams, Tech Ops teams, as well as external groups, in order to meet project timelines and deliver a highly consistent and robust viral vector production program.

Additional Job Responsibilities:

  • Assist in the development of analytical methods to study and characterize end of process material and in-process intermediates.
  • Serve as an SME for downstream purification applications when communicating with external groups.
  • Drafting and editing of standard operating procedures, analytical test methods, analytical sampling plans, technical documents, and batch records for regulatory or tech transfer purposes.
  • Source and assess new equipment and technologies in order to expand and improve purification capabilities.
  • Contribute to budget and goal planning of the overall viral vector group.
  • Successfully execute and document laboratory procedures and experiments with great attention to detail. 

Downstream Viral Vector Development - Qualifications:

  • Advanced degree with a background in chemical or biomedical engineering, biochemistry, cell & molecular biology, or related life science field is required. Doctoral degree or master’s degree with 5+ years or 8+ years post-graduate experience, respectively
  • Considerable direct experience with chromatography system design, operation, method development, scale-up, and troubleshooting experience (affinity, size-exclusion, ion exchange, monolithic columns, HIC) is required. Familiarity with AKTA systems and Unicorn software is preferred
  • Hands-on experience with various filtration systems (depth filtration, tangential flow filtration, microfiltration, diafiltration) is strongly desired
  • Familiarity with current principles, concepts, practices, and suppliers of a range of analytical techniques including: ELISA, qPCR, Octet, Luminex, MSD, electrophoresis (SDS-PAGE, W. Blot, CE) is expected
  • Previous experience serving as part of technology transfer teams or process development with external CMOs is strongly desired
  • Flow cytometry and mammalian tissue culture experience preferred
  • 2+ years of experience recruiting, and leading teams of junior scientists is preferred
  • Qualified candidates should be detail oriented with an ability to multi-task and meet deadlines in a fast-paced environment
  • Ability to mentor individuals to achieve organization, team and individual objectives while adhering to the company values (fearless, accountable, collaborative)
  • Must have excellent verbal and written communication skills
  • Must be proficient with MS Office and other commonly used software and technology programs

Benefits:

Adicet Bio offers both comprehensive benefits and Paid Time (PTO) plans for employees, which begin on the first day of employment, as well as the opportunity to work in a growing, dynamic environment.

Adicet Bio is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.

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