Scientist, Reagent Lyophilization at Mammoth Biosciences
South San Francisco, CA, US


Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. Mammoth aims to democratize disease detection with an easy and affordable point-of-care test that allows real-time and simultaneous detection of multiple conditions. By leveraging its internal research and development and exclusive licensing to Cas12, Cas13 and Cas14, Mammoth can provide enhanced diagnostics and genome editing for life science research, healthcare, agriculture, biodefense and more. Based in San Francisco, Mammoth Biosciences is co-founded by CRISPR pioneer Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Mayfield, NFX, and 8VC, Decheng, and leading individual investors including Brook Byers, Tim Cook, and Jeff Huber.


Mammoth is looking for a Reagent Lyophilization Scientist to work on a team of 3 scientists in charge of the reagent lyophilization development. This position is critical to Mammoth’s charter of using innovative CRISPR enzymes in diagnostic products. The Reagent Lyophilization Team is charged with developing the lyophilization cycles for Mammoth’s innovative CRISPR based detection reagent, transferring these into reagent manufacturing and executing the stability studies for all of Mammoth’s assay reagents.


Execute development, verification and stability studies to define the lyophilization cycle

Determine the protective excipients that adequately protect the reagents enzymes during lyophilization

Maintain and operate the analytical chemistry instruments (KF moisture analyzer, freeze dry microscope, differential scanning calorimeter) to measure properties of lyophilized reagents

Maintain and operate the team’s lyophilizers to produce lyophilized product for development and design transfer studies

Work with Mammoth’s contract manufacturing organizations to implement commercial lyophilization at the needed scale for successful assay commercialization

Execute experiments with Mammoth’s assay teams to determine efficacy of assay reagents during accelerated stability and real-time stability studies

Write plans, protocols and reports that are compliant with 21 CFR 820 and ISO 13485


A minimum of 3 years industry experience using chemistry or analytical chemistry methods to develop products.

Knowledge and experiences using analytical chemistry instruments.

Experiences with writing, executing and reporting on studies used in a regulated industry.

BS or MS in Chemistry, or Analytical Chemistry or Chemical Engineering


Experience using Karl Fisher moisture analyzers, freeze dry microscopes, and differential scanning calorimetry instruments

A minimum of 3 years industry experience on a product development team in the pharmaceutical or IVD field and using a 21 CFR 820 quality management system

Participation in the development of at least 3 different products and encompassing a majority of the product development phases of Concept and Feasibility, Design, Verification, Validation, Design Transfer, Product Launch, Product Support


Competitive salary with equity

Company-paid health/vision/dental benefits

Unlimited vacation and generous sick time

Free breakfast/lunch/dinner/barista

Free gym

Public transportation commuter subsidy

401(k) matching